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Some women experiencing extreme irritability or depression can benefit from a vitamin B12 injection

This high volume increases contamination risks without consistent sterile practices

Peripheral edema may be associated specifically with chronic liver disease or with tense ascites causing compression of the inferior vena cava and loss of intravascular oncotic pressure due to hypoalbuminemia, or it may be nonspecific from general debility

However, it is critical to recognize that clinical symptoms of deficiency can manifest without anemia or low serum vitamin B12 levels

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